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1.
Adv Healthc Mater ; 13(3): e2301753, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37820714

RESUMO

The work presented here introduces a facile strategy for the development of flexible and stretchable electrodes that harness the robust characteristics of carbon nanomaterials through laser processing techniques on a liquid crystal polymer (LCP) film. By utilizing LCP film as a biocompatible electronic substrate, control is demonstrated over the laser irradiation parameters to achieve efficient pattern generation and transfer printing processes, thereby yielding highly conductive laser-induced graphene (LIG) bioelectrodes. To enhance the resolution of the patterned LIG film, shadow masks are employed during laser scanning on the LCP film surface. This approach is compatible with surface-mounted device integration, enabling the circuit writing of LIG/LCP materials in a flexible format. Moreover, kirigami-inspired on-skin bioelectrodes are introduced that exhibit reasonable stretchability, enabling independent connections to healthcare hardware platforms for electrocardiogram (ECG) and electromyography (EMG) measurements. Additionally, a brain-interfaced LIG microelectrode array is proposed that combines mechanically compliant architectures with LCP encapsulation for stimulation and recording purposes, leveraging their advantageous structural features and superior electrochemical properties. This developed approach offers a cost-effective and scalable route for producing patterned arrays of laser-converted graphene as bioelectrodes. These bioelectrodes serve as ideal circuit-enabled flexible substrates with long-term reliability in the ionic environment of the human body.


Assuntos
Grafite , Polímeros , Humanos , Grafite/química , Reprodutibilidade dos Testes , Eletrodos , Microeletrodos , Encéfalo , Lasers
2.
Biosensors (Basel) ; 13(12)2023 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-38131773

RESUMO

Molecularly imprinted polymers (MIPs) have garnered significant attention as a promising material for engineering specific biological receptors with superior chemical complementarity to target molecules. In this study, we present an electrochemical biosensing platform incorporating MIP films for the selective detection of the interleukin-1ß (IL-1ß) biomarker, particularly suitable for mobile point-of-care testing (POCT) applications. The IL-1ß-imprinted biosensors were composed of poly(eriochrome black T (EBT)), including an interlayer of poly(3,4-ethylene dioxythiophene) and a 4-aminothiophenol monolayer, which were electrochemically polymerized simultaneously with template proteins (i.e., IL-1ß) on custom flexible screen-printed carbon electrodes (SPCEs). The architecture of the MIP films was designed to enhance the sensor sensitivity and signal stability. This approach involved a straightforward sequential-electropolymerization process and extraction for leaving behind cavities (i.e., rebinding sites), resulting in the efficient production of MIP-based biosensors capable of molecular recognition for selective IL-1ß detection. The electrochemical behaviors were comprehensively investigated using cyclic voltammograms and electrochemical impedance spectroscopy responses to assess the imprinting effect on the MIP films formed on the SPCEs. In line with the current trend in in vitro diagnostic medical devices, our simple and effective MIP-based analytical system integrated with mobile POCT devices offers a promising route to the rapid detection of biomarkers, with particular potential for periodontitis screening.


Assuntos
Técnicas Biossensoriais , Impressão Molecular , Polímeros Molecularmente Impressos , Polímeros/química , Interleucina-1beta , Sistemas Automatizados de Assistência Junto ao Leito , Impressão Molecular/métodos , Carbono/química , Técnicas Biossensoriais/métodos , Eletrodos , Técnicas Eletroquímicas/métodos , Limite de Detecção
3.
Light Sci Appl ; 12(1): 285, 2023 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-38001058

RESUMO

Optical gain enhancement of two-dimensional CsPbBr3 nanosheets was studied when the amplified spontaneous emission is guided by a patterned structure of polyurethane-acrylate. Given the uncertainties and pitfalls in retrieving a gain coefficient from the variable stripe length method, a gain contour [Formula: see text] was obtained in the plane of spectrum energy (ℏω) and stripe length (x), whereby an average gain was obtained, and gain saturation was analysed. Excitation and temperature dependence of the gain contour show that the waveguide enhances both gain and thermal stability due to the increased optical confinement and heat dissipation, and the gain origins were attributed to the two-dimensional excitons and the localized states.

4.
Medicine (Baltimore) ; 102(39): e35141, 2023 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-37773809

RESUMO

BACKGROUND: Wrist pain on the ulnar side is often caused by ulnar impaction syndrome (UIS). Idiopathic UIS requires surgical treatment when conservative treatment fails. The 2 main surgical procedures used are the wafer procedure and ulnar shortening osteotomy (USO) of the metaphysis or diaphysis. This review aimed to analyze comparative studies of the 2 procedures in UIS to determine clinical outcomes and complications. METHODS: One prospective and 5 retrospective comparison trials were retrieved from the PubMed, Embase, and Cochrane Library databases. The primary outcomes were treatment effectiveness; pain visual analog scale (VAS), disabilities of the arm, shoulder, and hand (DASH) score, Mayo wrist, and Darrow scores. The incidence of postoperative complications formed the secondary outcome. RESULTS: The selected studies included 107 patients who underwent the wafer procedure (G1) and 117 patients who underwent USO (G2). The wafer procedure had the benefits of less postoperative immobilization and an early return to work. However, there were no significant differences in the postoperative pain improvement and functional scores. All 6 studies reported high total complication rates and reoperation with USO. The most frequent complication was implant-related discomfort or irritation; subsequent plate removal was the most common reason for a secondary operation. CONCLUSIONS: There was no difference in pain improvement or the postoperative functional score between the groups. Nevertheless, postoperative complications were the major pitfalls of USO. As the specialized shortening system advances further, a high-level study will be necessary to determine the surgical option in UIS.


Assuntos
Artropatias , Humanos , Estudos Retrospectivos , Estudos Prospectivos , Artropatias/cirurgia , Articulação do Punho/cirurgia , Osteotomia/efeitos adversos , Osteotomia/métodos , Resultado do Tratamento , Artralgia/etiologia , Artralgia/cirurgia , Complicações Pós-Operatórias/epidemiologia
5.
J Orthop Trauma ; 37(3): e99-e103, 2023 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-36191348

RESUMO

OBJECTIVES: To analyze the risk factors associated with postoperative flexor tendon rupture, after a volar plate fixation of distal radius fractures. DESIGN: Retrospective observational case-control study. SETTING: Tertiary Care University Hospital in the Republic of Korea (2009-2020). PATIENTS: Sixteen referred patients were treated for flexor tendon rupture, following previously performed volar plating of distal radius fractures at other institutions. 16 patients were randomly selected from our database as controls, and were matched based on the Soong grade of the case group. INTERVENTION: Not applicable. MAIN OUTCOME MEASUREMENTS: Radial tilt and radial height were measured on anteroposterior radiographs. The volar tilt, tear drop angle, carpal translation, and Soong grade were measured in a lateral view. RESULTS: Quantitative measurements of the volar tilt, carpal translation, and tear drop angle were positively correlated with the flexor tendon rupture. The mean volar tilt and tear drop angle in the tendon rupture group were significantly smaller than those in the control group. The mean carpal translation in the tendon rupture group was significantly greater than that in the control group. CONCLUSIONS: This study demonstrated that volar tilt, carpal translation, and tear drop angle are significant risk factors for flexor tendon rupture, especially for plates placed at Soong grade 1 or 2. We suggest that the potential for tendon rupture because of incomplete reduction of the distal radius fracture along with implant prominence volar to the watershed line aggravates flexor tendon irritation at the distal edge of the plate because of distorted flexor tendon paths. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.


Assuntos
Fraturas do Rádio , Traumatismos dos Tendões , Fraturas do Punho , Humanos , Placas Ósseas/efeitos adversos , Estudos de Casos e Controles , Fixação Interna de Fraturas/efeitos adversos , Fraturas do Rádio/diagnóstico por imagem , Fraturas do Rádio/cirurgia , Fraturas do Rádio/complicações , Estudos Retrospectivos , Fatores de Risco , Ruptura/etiologia , Traumatismos dos Tendões/diagnóstico por imagem , Traumatismos dos Tendões/epidemiologia , Traumatismos dos Tendões/etiologia , Tendões
6.
J Colloid Interface Sci ; 634: 715-729, 2023 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-36563428

RESUMO

Small-scale and high-performance energy storage devices have drawn tremendous attention with their portable, lightweight, and multi-functionalized features. Here, we present a foldable supercapacitor with affordable flexibility by adopting a developed design and electrode material system as a way to extend usability. Notably, to resolve the limited energy density of conventional capacitors, we successfully synthesize the CoO/NiCo-layered double hydroxide (LDH) core-shell nanostructure on Ni framework as a cathode material. Further, glucose-based activated carbon (GBAC) is utilized for the anode. The CoO/NiCo-LDH electrodes exhibited a high specific capacitance of âˆ¼284.8 mAh g-1 at 1 A g-1, and GBAC delivers a high specific capacitance of âˆ¼166 F g-1 at 1 A g-1. In the following, the combinatorial integration of these materials enabled the asymmetric supercapacitor (ASC) to increase the energy density by enhancing the capacitance and the voltage window, in which a hydrogel-based electrolyte was facilitated for the foldable and wearable capability. The energy density of the ASC device was âˆ¼24.9 Wh kg-1 at a power density of âˆ¼779.5 W kg-1 with a voltage window of âˆ¼1.6 V. As demonstrated, a self-powered energy source was demonstrated by a serially connected multi-ASC device with a help of a commercial solar cell, which was employed for powering wearable healthcare monitoring devices, including personal alarms for patients and recording the human body's electrical signals. The present work offers a viable approach to preparing potential candidates for high-performance electrodes of supercapacitors with deformable configurations to extend the powering capability of other electronic devices with physical functionalities used in wearable electronics.


Assuntos
Carvão Vegetal , Dispositivos Eletrônicos Vestíveis , Humanos , Capacitância Elétrica , Eletricidade , Eletrodos , Glucose
7.
Microsyst Nanoeng ; 8: 98, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36119375

RESUMO

As a new concept in materials design, a variety of strategies have been developed to fabricate optical microlens arrays (MLAs) that enable the miniaturization of optical systems on the micro/nanoscale to improve their characteristic performance with unique optical functionality. In this paper, we introduce a cost-effective and facile fabrication process on a large scale up to ~15 inches via sequential lithographic methods to produce thin and deformable hexagonally arranged MLAs consisting of polydimethylsiloxane (PDMS). Simple employment of oxygen plasma treatment on the prestrained MLAs effectively harnessed the spontaneous formation of highly uniform nanowrinkled structures all over the surface of the elastomeric microlenses. With strain-controlled tunability, unexpected optical diffraction patterns were characterized by the interference combination effect of the microlens and deformable nanowrinkles. Consequently, the hierarchically structured MLAs presented here have the potential to produce desirable spatial arrangements, which may provide easily accessible opportunities to realize microlens-based technology by tunable focal lengths for more advanced micro-optical devices and imaging projection elements on unconventional security substrates.

8.
Clin Exp Pediatr ; 65(7): 330-336, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35681247

RESUMO

Several studies have reported changes in the prevalence of childhood fractures between the prepandemic and coronavirus disease 2019 pandemic periods considering the overall decrease in activity during the latter. This review aimed to organize and summarize the global trends in pediatric fracture incidence. Our findings should help predict fracture patterns in the postpandemic period by identifying changes in the past and present, thus aiding patient management.

9.
Sci Adv ; 8(15): eabn1646, 2022 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-35427152

RESUMO

Wound healing is the dynamic tissue regeneration process replacing devitalized and missing tissue layers. With the development of photomedicine techniques in wound healing, safe and noninvasive photobiomodulation therapy is receiving attention. Effective wound management in photobiomodulation is challenged, however, by limited control of the geometrical mismatches on the injured skin surface. Here, adhesive hyaluronic acid-based gelatin nanofibrous membranes integrated with multiple light-emitting diode (LED) arrays are developed as a skin-attachable patch. The nanofibrous wound dressing is expected to mimic the three-dimensional structure of the extracellular matrix, and its adhesiveness allows tight coupling between the wound sites and the flexible LED patch. Experimental results demonstrate that our medical device accelerates the initial wound healing process by the synergetic effects of the wound dressing and LED irradiation. Our proposed technology promises progress for wound healing management and other biomedical applications.

10.
Adv Sci (Weinh) ; 9(11): e2104629, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-35076161

RESUMO

Photobiomodulation (PBM) has received attention due to its potential for improving tissue function and enhancing regeneration in stroke. A lightweight, compact, and simple system of miniaturized electronic devices consisting of packaged light-emitting diodes (LEDs) that incorporates a flexible substrate for in vivo brain PBM in a mouse model is developed. Using this device platform, the preventive and therapeutic effects of PBM affixed to the exposed skull of mice in the photothrombosis and middle cerebral artery occlusion stroke model are evaluated. Among the wavelength range of 630, 850, and 940 nm LED array, the PBM with 630-nm LED array is proved to be the most effective for reducing the infarction volume and neurological impairment after ischemic stroke. Moreover, the PBM with 630 nm LED array remarkably improves the capability of spatial learning and memory in the chronic poststroke phase, attenuates AIM2 inflammasome activation and inflammasome-mediated pyroptosis, and modulates microglial polarization in the hippocampus and cortex 7 days following ischemic stroke. Thus, PBM may prevent tissue and functional damage in acute ischemic injury, thereby attenuating the development of cognitive impairment after stroke.


Assuntos
AVC Isquêmico , Terapia com Luz de Baixa Intensidade , Acidente Vascular Cerebral , Animais , Inflamassomos , Camundongos , Crânio
11.
Arch Orthop Trauma Surg ; 142(2): 197-203, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33048243

RESUMO

PURPOSE: The purpose of this study was to report the clinical outcome of revision arthroscopic triangular fibrocartilage complex (TFCC) foveal repair using a one-tunnel transosseous suture technique after failed primary TFCC repair. METHODS: Consecutive patients treated with arthroscopic TFCC foveal repair using the uniform one-tunnel transosseous suture technique after failed TFCC repair from 2014 to 2018 were retrospectively reviewed. The clinical outcome was evaluated using the Modified Mayo Wrist Score (MMWS) and the Quick Disabilities of the Arm, Shoulder, and Hand (Quick-DASH) score. The Visual Analog Scale (VAS) for pain, stability of the distal radioulnar joint (DRUJ), grip strength, and active range of motion (ROM) of the wrist joint also were assessed. RESULTS: This study cohort consisted of eight patients, and their mean time to revision after initial surgery was 15.1 months. Previous surgeries were performed using an arthroscopy-assisted mini-open TFCC repair in six cases, an arthroscopic all-inside repair in one case, and an arthroscopic transosseous suture technique in the remaining case. After revisional TFCC foveal repair, all patients demonstrated improved pain and a stable DRUJ. Participants showed improvement in grip strength and mean active wrist ROM. There was improvement in MMWS (from 58.6 to 87.5) and Quick-DASH score (from 46.9 to 12.2) during the mean follow-up of 15.6 months (range: 8-36 months). CONCLUSION: Based on the results of this study, remaining ulnar TFCC remnants may be appropriate for sufficient stable repair using an arthroscopic one-tunnel transosseous suture technique after failed primary repair. However, only a small number of patients was examined. A larger number has to be investigated to confirm the promising preliminary results. LEVEL OF EVIDENCE: Level IV, therapeutic case series.


Assuntos
Fibrocartilagem Triangular , Traumatismos do Punho , Artroscopia , Humanos , Estudos Retrospectivos , Técnicas de Sutura , Suturas , Fibrocartilagem Triangular/cirurgia , Traumatismos do Punho/cirurgia , Articulação do Punho/cirurgia
12.
Nanoscale ; 14(1): 175-186, 2021 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-34904989

RESUMO

Third harmonic generation (THG) has proven its value in surface and interface characterization, high-contrast bio-imaging, and sub-wavelength light manipulation. Although THG is observed widely in general solid and liquid substances, when laser pulses are focused at nanometer-level ultra-thin films, the bulk THG has been reported to play the dominant role. However, there are still third harmonics (TH) generated at the surface of the thin-films, not inside the bulk solid - so-called surface TH, whose relative contribution has not been quantitatively revealed to date. In this study, we quantitatively characterized the surface and bulk contributions of THG at ultra-thin ß-Ga2O3 nanomembranes with control of both the laser and thin-nanomembranes parameters, including the laser peak power, polarization state, number of layers, and nanomembranes thicknesses. Their contributions were studied in detail by analyzing the TH from freestanding ß-Ga2O3 nanomembranes compared with TH from ß-Ga2O3 nanomembranes on glass substrates. The contribution of the TH field from the ß-Ga2O3-air interface was found to be 5.12 times more efficient than that from the ß-Ga2O3-glass interface, and also 1.09 times stronger than the TH excited at bulk 1-µm-thick ß-Ga2O3. Besides, TH from the ß-Ga2O3-air interface was found to be 20% more sensitive to the crystalline structure than that from the ß-Ga2O3-glass interface. This research work deepens our understanding of surface and bulk THG from crystalline materials and provides new possibilities towards designing highly efficient nonlinear optical materials for bio-imaging, energy-harvesting, and ultrafast laser development.

13.
Small ; 17(52): e2105733, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34854553

RESUMO

Rotating cylindrical stamp-based nanoimprint technique has many advantages, including the continuous fabrication of intriguing micro/nanostructures and rapid pattern transfer on a large scale. Despite these advantages, the previous nanoimprint lithography has rarely been used for producing sophisticated nanoscale patterns on a non-planar substrate that has many extended applications. Here, the simple integration of nanoimprinting process with a help of a transparent stamp wrapped on the cylindrical roll and UV optical source in the core to enable high-throughput pattern transfer, particularly on a fabric substrate is demonstrated. Moreover, as a functional resin material, this innovative strategy involves a synergistic approach on the synthesis of molecularly imprinted polymer, which are spatially organized free-standing perforated nanostructures such as nano/microscale lines, posts, and holes patterns on various woven or nonwoven blank substrates. The proposed materials can serve as a self-encoded filtration medium for selective separation of formaldehyde molecules. It is envisioned that the combinatorial fabrication process and attractive material paves the way for designing next-generation separation systems in use to capture industrial or household toxic substances.


Assuntos
Polímeros Molecularmente Impressos , Nanoestruturas , Impressão
14.
Adv Mater ; 33(39): e2102530, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34355431

RESUMO

Triboelectric nanogenerators (TENGs) are put forward as a state-of-the-art energy-scavenging technology for self-powered electronics, but their severe wear and degradation driven by inevitable friction can pose significant durability and sustainability concerns. Here, an array of microfibers is reported that functions as a robust and sustainable TENG in both in-plane sliding and vertical contact-separation modes, with excellent electrical potential as high as 20 V and a high cyclability of 3000. The design flexibility of this microbrush TENG (MB-TENG) on the counter materials facilitates the further improvement of electrical outputs, benefiting numerous applications of human-interactive triboelectrification. Significantly, these MB-TENGs offer sufficient output power for successfully driving a smartwatch as well as an electromyography module. This technology uses a simple and cost-effective manner to provide a robust and reliable monolithic TENG module, which is expected to serve as a promising energy-harvesting source for self-powered electronics in the near future.

15.
Medicine (Baltimore) ; 100(28): e26445, 2021 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-34260526

RESUMO

RATIONALE: Several diseases feature tumors, or tumor-mimicking lesions, that further invade the bone and surrounding joints of the wrist region. Here, we describe 3 rare cases of multiple destructed carpal bones and adjacent joints in different disease entities confirmed via pathologic diagnosis. PATIENT CONCERNS: All 3 cases were examined between January 2016 and December 2019. Three patients presented with similar clinical manifestations and radiographic features, with multiple osteolytic lesions in the carpal bones and metacarpal bone base. DIAGNOSES: The 3 cases were diagnosed as diffuse type tenosynovial giant cell tumor, calcifying aponeurotic fibroma, and rheumatoid arthritis. INTERVENTIONS: Separate, experienced radiologist and pathologist took part in the interpretation and compartmentalization of radiographs and pathological findings, respectively. Even magnetic resonance imaging could not achieve a diagnosis; surgical excision was therefore required, with subsequent pathological assessment for treatment and final diagnosis. OUTCOMES: functional outcomes also differed among patients, poorest in rheumatoid arthritis patient. LESSONS: We report 3 rare disease entities, presenting with multifocal osteolytic lesions in the wrist. They all presented with similar clinical manifestations, and the final diagnoses were made via pathological evaluation. Compared with tenosynovial giant cell tumor and calcifying aponeurotic fibroma, rheumatoid arthritis had the poorest outcome.


Assuntos
Artrite Reumatoide/patologia , Ossos do Carpo/patologia , Fibroma Ossificante/patologia , Tumor de Células Gigantes de Bainha Tendinosa/patologia , Neoplasias de Tecidos Moles/patologia , Artrite Reumatoide/diagnóstico , Ossos do Carpo/diagnóstico por imagem , Diagnóstico Diferencial , Feminino , Fibroma Ossificante/diagnóstico , Tumor de Células Gigantes de Bainha Tendinosa/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Osteólise/diagnóstico por imagem , Osteólise/patologia , Neoplasias de Tecidos Moles/diagnóstico
16.
Skeletal Radiol ; 50(9): 1855-1861, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33725169

RESUMO

OBJECTIVE: The purpose of this study was to identify the location of lunate chondromalacia and to compare the difference in location according to presence or absence of triangular fibrocartilage complex (TFCC) foveal tear, which induces distal radioulnar joint (DRUJ) instability. METHODS: We performed a retrospective study of 97 patients (102 wrists) who were diagnosed with and treated for idiopathic ulnar impaction syndrome (UIS) between 2014 and 2018. Subjects were divided into two groups according to presence or absence of TFCC foveal tear with DRUJ instability. Group I had UIS without a TFCC foveal tear (52 wrists, mean age of 43.2 years), while Group II had UIS with a TFCC foveal tear (50 wrists, mean age of 45.3 years). There was no significant difference in age, sex, or duration of symptoms between the two groups. All patients underwent wrist MR Arthrography (MRA) in the same gantry, and all scanned coronal sections of the lunate were standardized into 10 slices, including the whole anteroposterior width of the lunate. Each slice was sequentially numbered from dorsal to volar side, and the location of chondromalacia was marked in each numbered section. Radiological parameters including ulnar variance and ulnolunate distance (ULD), which indicated the distance between the ulnar head and lunate, were measured in the wrist series. RESULTS: The most frequent location of lunate chondromalacia was slightly to the volar side of the lunate in both groups. Group I showed a higher frequency of chondromalacia in the volar side of the lunate. In Group II, chondromalacia was identified with high frequency not only on the volar side of the lunate but also on the dorsal side. In other words, Group II showed broader chondromalacia in the lunate. There was no significant difference in ulnar variance (Group I, 3.19 ± 1.42 mm; Group II, 2.76 mm ± 1.67 mm) or ulnolunate distance (Group I, 1.66 ± 0.94 mm; Group II, 2.05 mm ± 0.87 mm). The average ULD decreased during radial deviation but increased during ulnar deviation. CONCLUSION: This study showed that lunate chondromalacia associated with idiopathic ulnar impaction syndrome occurs more frequently on the volar side of the lunate. Also, TFCC foveal tear, which causes DRUJ instability, leads to broader lunate chondromalacia in idiopathic ulnar impaction syndrome. Therefore, further analysis of the pattern of lunate chondromalacia can provide a clue for DRUJ instability.


Assuntos
Doenças das Cartilagens , Fibrocartilagem Triangular , Traumatismos do Punho , Adulto , Doenças das Cartilagens/diagnóstico por imagem , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Fibrocartilagem Triangular/diagnóstico por imagem , Traumatismos do Punho/diagnóstico por imagem , Articulação do Punho/diagnóstico por imagem
17.
Biomater Sci ; 8(22): 6261-6271, 2020 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-33016275

RESUMO

Peripheral nerve injury results in significant sensory and motor functional deficits. Although direct neurorrhaphy in the early phase may reduce its devastating effects, direct end-to-end neurorrhaphy is sometimes impossible owing to a defect at the injured site of the nerve. Autogenous nerve graft is a primary consideration for peripheral nerve defects; however, significant morbidity of the donor site is inevitable. Recently, the treatment using engineered synthetic nerve conduits has been regarded as a promising strategy to promote the regeneration of peripheral nerve defects. In this study, we developed longitudinally oriented collagen hydrogel-grafted elastic nerve guidance conduits (NGC) to reconstruct sciatic nerve defects. An elastic NGC was prepared by using poly(lactide-co-caprolactone) (PLCL), and electrospun PLCL was adopted to fabricate nanoporous structures with appropriate permeability for nerve regeneration. Oriented collagen hydrogels were prepared by the 3D printing method to achieve a microscale hydrogel pattern. Based on sciatic nerve injury models in rats, we confirmed the beneficial effects of the NGC with 3D printed collagen hydrogel on axonal regeneration and remyelination along with superior functional recovery in comparison with the NGC filled with the bulk collagen hydrogel. It is believed that the aligned collagen hydrogels provide a preferable environment for nerve regeneration, functioning as an oriented guidance path. In conclusion, the PLCL nerve guide conduit containing a 3D printed aligned collagen hydrogel can be useful for peripheral nerve regeneration.


Assuntos
Hidrogéis , Regeneração Nervosa , Animais , Colágeno , Porosidade , Impressão Tridimensional , Ratos , Ratos Sprague-Dawley
18.
Clin Biomech (Bristol, Avon) ; 76: 105021, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32416405

RESUMO

BACKGROUND: Comparative studies of the biomechanical effects of plates of varying lengths and different screw insertion angles on allograft spacers are lacking. METHODS: Finite element model analysis of a previously validated, three-dimensional, intact cervical spinal segment model of C3-6 was conducted in the present study. On the C5-6 segment, anterior discectomy and fusion were performed using allograft spacers and different combinations of anterior plates and screws. The biomechanical characteristics of combinations of short, medium, and maximal length plates with screw insertion angles of 0°, 8°, 16°, and 32° were analyzed. FINDINGS: In flexion and extension, the risk of allograft spacer subsidence decreased as screw angles increased. Short plates with a screw insertion angle of 32° posed the lowest subsidence risk, similar to medium length plates with a screw insertion angle of 16°, in all motion conditions. The risk of bone yielding increased as plate length increased, but decreased as the screw insertion angle increased. INTERPRETATION: Short plates with a large screw insertion angle (32°) showed the highest mechanical stability and load sharing of allograft spacers and the lowest risk of screw loosening. Accordingly, we recommend the use of a short plate and large screw insertion angle for anterior cervical discectomy and fusion.


Assuntos
Placas Ósseas , Parafusos Ósseos , Vértebras Cervicais/cirurgia , Análise de Elementos Finitos , Aloenxertos/cirurgia , Fenômenos Biomecânicos , Humanos , Transplante Homólogo
19.
Arthroscopy ; 36(7): 1845-1852, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32275939

RESUMO

PURPOSE: To compare outcomes at different time periods following arthroscopic triangular fibrocartilage complex (TFCC) transosseous foveal repair within 6 months, between 6 and 12 months, and more than 12 months from injury. METHODS: Consecutive patients treated with arthroscopic TFCC foveal repair using the uniform one-tunnel transosseous suture technique by a surgeon from 2014 to 2017 were retrospectively reviewed. The patients were assigned to 1 of 3 groups according to time between injury and surgery. Pain visual analog scale (VAS); grip strength; modified Mayo wrist score (MMWS); Quick disabilities of the arm, shoulder, and hand (QuickDASH) score; and distal radioulnar joint stability were assessed at minimum 2 years postoperatively, along with minimal clinically important difference, and overall patient satisfaction. RESULTS: This study cohort consisted of 80 patients: group A (<6 months, n = 38), group B (6-12 months, n = 20), and group C (>12 months, n = 22). No differences were found among groups in VAS, grip strength, and MMWS and QuickDASH. Overall, patients exhibited significant functional improvement at 2 years (VAS: 3-0, P < .001; grip strength: 77.1%-95.6%, P < .001; MMWS: 65-90, P < .001, QuickDASH: 20.5-4.5, P < .001). Median changes in outcome variables and the proportion of patients achieving minimal clinically important difference for the QuickDASH were similar among groups. Seventy-eight patients (97%) achieved distal radioulnar joint stability, and 70 patients (87%) were satisfied with treatment. CONCLUSIONS: Although this current study has insufficient statistical power, the available data suggest that patients with a TFCC foveal tear who underwent arthroscopic transosseous repair surgery more than 12 months after injury could expect to experience similar functional improvement compared with patients who underwent surgery within 6 months or between 6 and 12 months following injury. LEVEL OF EVIDENCE: Level III, retrospective comparative study.


Assuntos
Artroscopia/métodos , Técnicas de Sutura , Tempo para o Tratamento , Fibrocartilagem Triangular/lesões , Fibrocartilagem Triangular/cirurgia , Adulto , Feminino , Humanos , Masculino , Diferença Mínima Clinicamente Importante , Medição da Dor , Recuperação de Função Fisiológica , Estudos Retrospectivos , Adulto Jovem
20.
Sensors (Basel) ; 20(3)2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-32024153

RESUMO

Detecting earthquakes using smartphones or IoT devices in real-time is an arduous and challenging task, not only because it is constrained with the hard real-time issue but also due to the similarity of earthquake signals and the non-earthquake signals (i.e., noise or other activities). Moreover, the variety of human activities also makes it more difficult when a smartphone is used as an earthquake detecting sensor. To that end, in this article, we leverage a machine learning technique with earthquake features rather than traditional seismic methods. First, we split the detection task into two categories including static environment and dynamic environment. Then, we experimentally evaluate different features and propose the most appropriate machine learning model and features for the static environment to tackle the issue of noisy components and detect earthquakes in real-time with less false alarm rates. The experimental result of the proposed model shows promising results not only on the given dataset but also on the unseen data pointing to the generalization characteristics of the model. Finally, we demonstrate that the proposed model can be also used in the dynamic environment if it is trained with different dataset.

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